NAD+
Nicotinamide adenine dinucleotide (a coenzyme, not a peptide)
A coenzyme found in every living cell, central to energy metabolism and DNA repair. It is not a peptide, but many peptide suppliers sell it, so we include it here.
Structure
Evidence at a glance
Where the published research on NAD+ comes from, by type of study.
Cell studies
Redox reactions, sirtuin and PARP enzyme activity, and mitochondrial function.
Animal studies
Ageing and metabolic studies in mice, often using precursors such as NR and NMN.
Human studies
Trials mostly test oral precursors (NR, NMN). Evidence for injected NAD+ is limited.
Research areas
What laboratories have studied NAD+ for, and in which models. These are research questions, not proven uses.
Sirtuins and PARPs
Enzyme assays- Required substrate for sirtuin and PARP enzymes.
- Used to study DNA repair and protein deacetylation.
Mitochondrial function
Isolated mitochondriaCell culture- Central electron carrier in glycolysis and oxidative phosphorylation.
Ageing models
Aged mice- NAD+ levels fall with age in several tissues in mice.
Legal status
NAD+ is not an approved medicine anywhere we cover. Suppliers may sell it for laboratory research only, and regulators judge that by the whole website, not the label.
United States Varies by form
Not an approved drug for injection. Oral precursors are sold as dietary supplements under separate rules.
United Kingdom Varies by form
Not a licensed medicine. Food supplement rules apply to some oral forms.
European Union Varies by form
Not an authorised medicine. Novel food rules apply to some precursors.
Sport Not listed
Not named on the WADA Prohibited List. Check rules on infusion volume.
Lab handling
General good practice for research materials. Follow the supplier's datasheet where it differs.
Storage
Keep the sealed material at −20 °C, dry and away from light. Let the vial reach room temperature before opening to stop condensation.
Solubility
Freely soluble in water; protect solutions from light and heat. Add solvent down the vial wall and swirl gently rather than shaking.
Aliquots
Split solutions into single-use aliquots, label with lot number and date, and freeze. Avoid repeated freeze-thaw cycles.
Work out your stock solution
Stock concentration, molarity and dilutions for NAD+, using MW 663.43 g/mol.
Before you buy for your lab
Tick each check as you confirm it with the supplier. Do not order until all six are done.
Questions researchers ask
What is NAD+?
A coenzyme found in every living cell, central to energy metabolism and DNA repair. It is not a peptide, but many peptide suppliers sell it, so we include it here.
What is the molecular weight of NAD+?
About 663.43 g/mol. Use the figure on your batch certificate of analysis.
Is NAD+ approved for human use?
No. Not an approved drug for injection. Oral precursors are sold as dietary supplements under separate rules.
How should NAD+ be stored in the lab?
Keep the sealed material cold, dry and away from light, typically at −20 °C. Once in solution, split it into single-use aliquots and freeze to avoid repeated freeze-thaw cycles.
Does this page give doses?
No. We publish laboratory and educational information only, never doses, injection guidance or treatment advice.
Is NAD+ a peptide?
No. NAD+ (nicotinamide adenine dinucleotide) is a coenzyme made of two nucleotides. It is listed here because it is often sold alongside research peptides.
NAD+ vs NADH: what is the difference?
NAD+ is the oxidised form and NADH the reduced form of the same coenzyme. Together they carry electrons in cellular metabolism.
NAD+ vs NMN: what is the difference?
NMN (nicotinamide mononucleotide) is a precursor that cells convert into NAD+. NAD+ is the active coenzyme itself.
Is NAD+ legal?
Oral precursors such as NR are sold as dietary supplements in the US. Injectable NAD+ is not an FDA-approved drug. In the UK and EU, status depends on the form and the claims made.
Is NAD+ banned by WADA?
NAD+ is not named on the WADA Prohibited List, but WADA limits intravenous infusions and injections above 100 mL per 12 hours.
